مستخلص الطحالب الدوناليلا سالينا لعلاج مرض السكري ومرض الزهايمر

Diabetic Resultsshowedthattotallipid(TL),totalcholesterol(TC)andtriglycerides(TG),adhesionmolecules(ICAM-1andVCAM-1)possessedasignificantincreaseinSTZ-induceddiabeticratsmodel.D.salinaethanolicextractremediationofdiabeticratsamelioratedTC,TG,ICAM-1andVCAM-1towerednormalcontrollevels.FromhistopathologicalpointofviewSTZ-induceddiabeticratsshoweddeteriorativemodificationsinthecardiacarchitecture.While,supplementationofdiabeticratswithD.salinaextractdemonstratedanimprovementinhearttissue.Hence,itcouldbededucedthat,D.salinaextractshowedtherapeuticapproachesinhyperglycemiadominance. Al-zheimer SignificantincreaseinoxidativestressbiomarkersassociatedwithsignificantdecreaseintheantioxidantenzymesactivityinAlintoxicatedraswasrevealed.SignificantdepletioninbrainATPaseenzymeactivitywhile,significantincreaseincaspase-3activitywasdetected.Moreover,significantelevationsinbrainacetylcholineesterase(ACHE)activityaccompaniedwithsignificantreductionindopamine(DA),noradrenaline(NA),adrenaline(A),serotonin(5-HT)levelswererecorded.MarkedameliorationwasdetectedinallinvestigatedneurologicalbiomarkersupontreatmentofADratswithD.salinaextractincomparisonwithDonepezilreferencedrug.Theseresultswereconfirmedbyhistologicalexaminationofbrainsections.Hence,thecurrentresultsclearlyindicatedneuromodulatingeffectofD.salinaagainstAlzheimer’sdisease.