Cotton having a multifunctional properties is on focus research using different processes and materials. Functionalised cotton fabric with thermoresponsive nanoparticles have been studied to improve cotton properties. During this research silver nanoparticle (AgNPS) have been synthetized using poly(N-isopropylacrylamide)/polyethyleneimine nanogel as reducing and stabilising agent. Prepared AgNPs have been characterised and proved their particle size in range of (6 – 10 nm). Furthermore, nanogel with AgNPs have been treated with silicon compound to produce organosilicon hybrid materialspolyethyleneiminesilver nanoparticles nanogel. Produced nanogel have been characterised for their pH, temperature, textural, rheological, antimicrobial, cytotoxicity and conductivity properties. Further investigation were going to treated fabric and proved that, treated fabric have pH and thermo-responsive, antibacterial and conductivity properties