Thetreatmentofmaleratswithstreptozotocin(STZ)toinducediabetesincreasedlevelsoftumornecrosisfactoralpha(TNF-α(,interlukine1β(IL-1β(,tumorgrowthfactorβ(TGF-β(,theapoptosisratesandthealterationsofthepro-apoptosis(eotaxin,caspase-1andcaspase-2)andinflammation(NF-κB1andAIF-1)relatedgenes.While,markedreductioninparaoxanase1(PON1)levelwasdetectedinSTZ-induceddiabeticrats.However,treatmentofSTZ-exposedratswithredandwhiteberryextractsexhibitednoticeableameliorationsinTNF-α,IL-1β,TGFβlevelsandPON1activityaswellaslowapoptosisratesanddecreasedthealterationofthepro-apoptosisandinflammatoryrelatedgenesinducedbySTZinmalerats.Berryextractsexhibitedattenuationinantioxidantstatus,suppressedinflammatorycytokines,apoptosisandthealterationsintheapoptosisandinflammatoryrelatedgenesinducedbySTZin male rats.
Al-zheimer
Markedlyelevationinlipidpyroxide,apoptoticmarkerenzyme(caspase-8)andcalmodulinlevelswhile,reducedglutathione(GSH)levelandanti-inflammatoryenzyme;paraoxanase-1(PON1)werereducedinADwhencomparedwithnormalcontrolrats.ThetreatmentofmaleratswithAlCl3inducedADwasassociatedwithincreaseinthe8-OHdG/2-dGratioanddecreaseintheexpressionofDHCR24andFKBP1Bgenes.However,thetreatmentofAD-inducedratswithredandwhiteberryextractsexhibitedlow8-OHdG/2-dGratioandhighexpressionoftheDHCR24andFKBP1Bgenes.Theseresultssuggestedthat,theneuroameliorativeeffectofberryextractscouldbeattributedtotheinhibitionofreactiveoxygenspecies(ROS)production,increasetheactivityoftheantioxidantenzymesaswellasinhibitingtheoccurrenceofapoptoticrelatedenzymessuchascaspases-8.
